New Trends in the Probiotics Industry: What Start-ups Need to Know

The probiotics industry is really taking off right now. With ongoing research into the microbiome, the market for probiotics is constantly expanding, creating exciting opportunities for innovation and advancement. If you are new to this industry as a start-up and aiming to stand out, you must consider these trends to get into the market stronger and, most importantly, to stay in the industry for a long time. Let's take a closer look at these trends and discuss how start-ups can use the opportunity to establish a healthy presence.

Personalized Probiotic Solutions

The last decade saw an exciting shift towards personalized solutions following genetic and microbiome research advancements. The new idea behind probiotics is to provide personalized or precision treatment that considers the individual's specific characteristics rather than relying on a one-size-fits-all approach.

A personalized probiotic treatment method was proposed and tested in animal models for intestinal disorders. Researchers isolated beneficial bacteria from the gut microbiota of healthy individuals and stored them. Then, these bacteria were successfully used as a therapy for diseases related to gut microbial imbalances. This approach suggests that by isolating commensal bacteria in a personalized manner, it may be possible to aid the colonization process based on the unique genetic characteristics of the host.

If you're starting a probiotic company, think about creating products that can be customized based on individual microbiome profiles. This could involve investing in research and development to develop personalized probiotic formulations. Working with genetic testing and microbiome analysis companies could add value to your brand. Also, using customer data to give personalized recommendations can help you build stronger customer relationships.

Next-Gen Innovations

Scientists have made fascinating discoveries about the trillions of microorganisms in our gut. These findings have paved the way for developing next-generation probiotics (NGPs), a variety of microorganisms that may transform our approach to gut health. Unlike the probiotics you might be familiar with, like lactobacilli and bifidobacteria, NGPs include species like Eubacterium spp., Roseburia intestinalis, Bacteroides spp., Akkermansia muciniphila, Faecalibacterium prausnitzii. These tiny life forms carry significant potential as they can enhance our immune system, guard against specific illnesses such as cancer, and generate beneficial compounds like short-chain fatty acids.

Currently, researchers in academia and industry are focused on discovering novel strains of gut microbes to create more advanced probiotic products. Studies on applying probiotics and NGPs to treat or prevent various human health issues have gained momentum. The research focuses on the interactions between probiotic microorganisms, human cells, and pathogenic microbes. NGPs come from genera not traditionally utilized as probiotics and are expected to be administered under drug regulatory frameworks.

Expansion into New Markets

Using probiotics only for better gut health is not the only way to market a new product. The critical information to remember is - probiotics already found their way into new markets, such as mental health, skincare, cleaning, cosmetic and specific treatments. Increasing consumer awareness of the wide-ranging benefits of probiotics beyond just improving gut health is another reason to consider a new product line. Probiotics have been suggested as potential components of both preventive and immediate care strategies for COVID-19 infection due to their ability to modulate the immune system and the observed effectiveness of specific probiotics in preventing upper respiratory tract viral infections. In a study conducted in France, it was found that adding a multi-strain probiotic formulation to standard therapy for hospitalized COVID-19 patients led to lower rates of illness and death. You can identify a new -unserved- market to develop products and always do your search for a piece of science-backed information to establish your technology. Also, analyzing the applications for new areas and investing in marketing campaigns to educate your customers about the broader benefits of probiotics can help you build trust.

Regulatory Advancements

The regulatory landscape for probiotics is different today than fifteen years ago. The regulation and marketing of probiotics were initially established within the food industry. However, these approaches are now anticipated to impact the pharmaceutical and health sectors, necessitating further examination of regulatory frameworks. The new guidelines can pose challenges while establishing standards for probiotic products. The regulatory standards for probiotics differ from country to country, affecting their use in various products, health claims, labeling, and user communication.

Some countries have established effective regulatory frameworks and supported evidence-based probiotic claims. However, in other countries, approved claims are rare, resulting in limited communication about the health benefits of probiotics in the market. The stringent requirements and extensive market size within the European framework greatly influence the future of industry-driven probiotic research. Hence, the scientific and technical standards for introducing probiotics products to the market and making claims differ significantly around the globe.

Probiotic start-ups in various regions and under diverse legal frameworks must ensure their actions and decisions align with the different regulatory and compliance requirements specific to each jurisdiction. It is crucial to stay informed about the unique legal, financial, and operational considerations in each location where they conduct business to maintain legal compliance, promote ethical conduct, and mitigate risks.

Scientific Improvements

When we look at history, there were only around sixty thousand studies about probiotics between 2000 and 2012. In the last twelve years, between 2012 and 2024, the number almost doubled the score by over a hundred thousand probiotics studies. The most significant factor for industry enthusiasm comes from scientific improvements. As scientific knowledge about probiotics and their mechanisms grows, new strains with unique benefits have been discovered, leading to a flourishing probiotics market. Ongoing research focuses on understanding traditional probiotics more deeply to determine optimal dosages for maximum benefits. For start-ups in this industry, establishing partnerships with universities and research institutions can provide a solid foundation for sustainable business growth.

Key takeout for start-ups!

The probiotics industry presents plenty of opportunities for start-ups. By staying informed about the latest trends and strategically positioning themselves, start-ups can survive and thrive in this competitive landscape. Personalized solutions, expansion into new markets, regulatory advancements, scientific progress, and sustainability are key areas to focus on. Adopting these trends can help start-ups innovate, attract investment, and build a loyal customer base.

It's important to remember that the probiotics market is not just about following trends but also about setting them. With the right approach, your start-up can be at the forefront of the next big wave in probiotics.

REFERENCES

• Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., & Obis, D. (2021). Shaping the future of probiotics and prebiotics. Trends in Microbiology, 29(8), 667–685.

• d’Ettorre, G., Ceccarelli, G., Marazzato, M., Campagna, G., Pinacchio, C., Alessandri, F., Ruberto, F., Rossi, G., Celani, L., & Scagnolari, C. (2020). Challenges in the management of SARS-CoV2 infection: The role of oral bacteriotherapy as complementary therapeutic strategy to avoid the progression of COVID-19. Frontiers in Medicine, 7, 389.

• De Filippis, F., Esposito, A., & Ercolini, D. (2022). Outlook on next-generation probiotics from the human gut. Cellular and Molecular Life Sciences, 79(2), 76.

• Dronkers, T., Krist, L., Van Overveld, F., & Rijkers, G. (2018). The ascent of the blessed: Regulatory issues on health effects and health claims for probiotics in Europe and the rest of the world. Beneficial Microbes, 9(5), 717–723.

• Heinken, A., Khan, M. T., Paglia, G., Rodionov, D. A., Harmsen, H. J., & Thiele, I. (2014). Functional metabolic map of Faecalibacterium prausnitzii, a beneficial human gut microbe. Journal of Bacteriology, 196(18), 3289–3302.

• Jahanshahi, M., Maleki Dana, P., Badehnoosh, B., Asemi, Z., Hallajzadeh, J., Mansournia, M. A., Yousefi, B., Moazzami, B., & Chaichian, S. (2020). Anti-tumor activities of probiotics in cervical cancer. Journal of Ovarian Research, 13(1), 1–11.

• Momtaz Al-Fakhrany, O., & Elekhnawy, E. (2024). Next-generation probiotics: The upcoming biotherapeutics. Molecular Biology Reports, 51(1), 505.

• Olveira, G., & González-Molero, I. (2016). An update on probiotics, prebiotics and symbiotics in clinical nutrition. Endocrinología y Nutrición (English Edition), 63(9), 48.